Cambodia reports H5N1 avian influenza clade is 220.127.116.11c
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in H5N1 Avian Influenza Follow-up Cases reported in Cambodia this week, the Cambodian Center for Disease Control announced them Facebook page The day that was determined as the clade is 18.104.22.168c.
This is what they wrote (computer compiler):
Currently, February 26, 2020
The H5N1 avian influenza virus, which caused the death of girls living in Rolang village, Khlach town, Central Sitha district, is a virus that has been studied among domestic birds and wild birds in Cambodia over the past few years.
H5N1 avian influenza (clade 22.214.171.124c): different from H5N1 in other countries around the world.
Monitoring of the disease is ongoing, while residents in contact with the patient are kept under surveillance.
Until today, there has been no clear evidence of human-to-human transmission of the H5N1 avian influenza virus.
Ask all citizens to avoid direct harm to sick or dead birds. Let’s protect and prevent together for our health.
For more information, please call 118
from Global Health Organization:
A (H5) viruses from birds and non-human mammals characterized from September 2022 to February 2023 belong to the following clusters:
Claid 126.96.36.199a Viruses have been detected in poultry in Bangladesh. There were up to 10 amino acid substitutions in the HA of modern viruses compared to the HA of A/duck/Bangladesh/17D1012/2018, from which candidate vaccine viruses (CVV) were developed. Some of the newer viruses did not interact well with the post-infection ferret antisera raised against A/duck/Bangladesh/17D1012/2018 CVV but instead interacted well with the anti-ferret serum raised against A/duck/Bangladesh/19097/2013 CVV.
Clade 188.8.131.52c Viruses have been detected in birds in Viet Nam and the Lao People’s Democratic Republic. Viruses from Vietnam reacted well with post-infection ferret anti-serum raised against A/duck/Vietnam/NCVD1584/2012 CVV, despite recent strains containing up to 9 amino acid substitutions in the HA.
Clade 184.108.40.206e Viruses detected in Timor-Leste. The HAs of these viruses were closely related to viruses previously discovered in Indonesia. No representative CVVs of this HA branch and viruses from Timor-Leste reacted poorly with ferret antisense after infection raised against clade 220.127.116.11a and 18.104.22.168c CVVs. No human infection has been linked to viruses from this branch and the extent of their circulation is uncertain.
Clade 22.214.171.124b Viruses have been detected in birds in many countries in Africa, Asia, Europe and North America, and for the first time in Central and South America. An increasing number of infections have been reported in wild and captive mammals, with suspected transmission from mink to mink at a farm in Spain. Viruses from this branch have been associated with many different NA subtypes with N1 now prevalent. High levels of bird infection with these viruses and increased geographic distribution are associated with genetic diversity. Some A (H5N1) viruses from Europe, the United States of America (USA) and Vietnam show low reactivity with ferret antisera raised against A/Astrakhan/3212/2020 CVV. All viruses from Europe reacted well with post-infection ferret antisera raised against A/chicken/Ghana/AVL763_21VIR7050-39/2021; The CVV model is being developed. Several viruses from USA that had reduced interaction with ferret antigens raised against A/Astrakhan/3212/2020 CVV showed better reactivity with ferret antigens after infection raised against A/American wigeon/South Carolina/22-000345-001/ 2021.
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the US Centers for Disease Control and Prevention He writes: HPAI A (H5N1) virus infections have been reported in more than 880 people with a fatality rate of approximately 50% since 1997, including 20 cases and 7 deaths in Hong Kong during 1997-2003, and more than 860 cases have been reported. reported in 21 countries since November 2003. Mild symptoms of upper respiratory tract disease, lower respiratory tract disease, severe pneumonia with respiratory failure, encephalitis, and multi-organ failure have been reported. One case of asymptomatic infection was reported in Vietnam in 2011, and another asymptomatic case was reported in the United Kingdom that occurred in late 2021. The extent of disease caused by human infection with current H5N1 avian influenza virus is unknown. Since 2016, a small number of sporadic infections have been reported each year globally. The severity of human disease in all cases of avian influenza virus infection ranged from no symptoms or mild disease to severe disease leading to death.